Astragalus

Astragalus Extrakt ein wichtiges AntiAging und Antikrebs-Mittel mit höchstem Zukunftspotential

 

Astragalus als AntiAging-Mittel

Telomere_caps WikipediaAstragalus membranaceus wird seit längerem als wichtiges potentielles Antiaging Mittel beforscht:

kann doch Astragalus-Extrakt die bei jeder Zellteilung kürzer werden „Endkappen“ der Chromosomen, die s.g. TELOMERE, wieder verlängern helfen.

Wenn die Telomere durch zahlreiche Zellteilungen abgeknabbert sind, geht die Zelle entweder zugrunde (Apoptose) oder in einen senescenten Ruhezustand über (in welchem sie erhöht anfällig für Mutationen und Entartungen ist).

 

Astragalus-Extrakt kann Telomere verlängern

Eine spannende Review aus 2012 zeigt dass dies ohne „Krebsaktivierung“ möglich ist und man so „gealterte Zellen“ wieder deutlich verjüngen kann, hier die Übersichtsarbeit als FullTextPDF.

Mäuse unter Astragalus-Nahrungsergänzung zeigten eine Verbesserung vieler wichtiger Stoffwechselparameter:

  • Glucose Toleranz
  • Osteoporose
  • Haut-Gesundheit
  • ohne jede erhöhung einer Krebs-Bildungs-Neigung.

Die Telomer-Verlängerung ist einer der wichtigsten HotSpots aller Antiaging-Bemühungen, bis jetzt war nur Fasten als beeinflussender Faktor bekannt.

 

Telomere können vermessen werden?

Bereits 2011 gab es einen Spiegel-Artikel über diese „Zündschnüre des Lebens“ und deren Messung: je länger die Telomere, desto länger kann man noch leben.

Die spanische Firma LifeLength bietet diese Messungen um ca. 500,- an, mittlerweile gibt es noch einige andere Firmen wie zB Telomer-Diagnostics.

LEIDER SIND JETZT – 2016 – DIE WEBSITES DER HIER ZITIERTEN FIRMEN NICHT MEHR ONLINE. Ich habe aktuell auch keine andere kommerzielle Firma gefunden, welche Telomer-Messungen durchführt.

 

Telomer-Messung nach Dr. Yoshiaki Omura

Omura Yoshiaki in Los Angeles Frühling 2016

Dr. Omura hat ein patentiertes Resonanz-Test-Verfahren entwickelt, mit dem man die Telomer-Länge abschätzen kann. Wir waren im Frühling 2016 in Los Angeles bei Dr. Omura und werden ihn noch öfters besuchen und sicherlich die Telomer-Messung und andere Messsungen nach Omura bei uns in der Praxis etablieren.

 

AntiAging-Spezialist Dr. Zöch, Krems

Zöch Wolfgang

Dr. Zöch beschäftigt sich seit längerem wissenschaftlich mit den Mechanismen des Telomer-Verlustes (Hayflick-Grenze) und der Telomer-Verlängerung.

Dr. Wolfgang Zöch, Spezialist für AntiAging-Medizin und biologische Tumor-Therapie berichtet nach Einnahme von Astragalus eine bemerkenswerte Verbesserung seiner Energie und Grundbefindlichkeit.

Leider ist Dr. Zöch mittlerweile in Pension gegangen, für spezielle Anfragen steht er jedoch sicher gerne zur Verfügung.

 

Astragalus Extrakt konnte tatsächlich bei langzeit-Einnahme „verjüngen“

ich bin über folgende sehr spannende Website gestolpert, bei der ein Interview mit Einem langzeit Astragalus-Verwender wiedergegeben wird:  http://joshmitteldorf.scienceblog.com – Josh Mitteldorf hat ein super Blog mit AntiAging-Strategien

Interview rüberkopiert zur Sicherheit als BAK

falls das Blog verschwindet, was längerfristig häufig der fall ist hab ich hier dieses interessante und wichtige Interview rüberkopiert auf meine Seite – natürlich ist das Copyright bei der Ursprünglichen Seite die ich oben zitiert habe.

this text is copied from above cited website only to keep a backup in case the blog disappears. The Copyright for Text and pictures is of course entirely with JoshMittteldorf who runs a very exciting blog about AntiAging-Strategies.

 

A one-man experiment in radical anti-aging

One reason that there is still so much uncertainty in anti-aging medicine is that we can’t do experiments on humans the way we do on mice.  So we are grateful for a few human guinea pigs who put their own bodies on the line as early adopters.  There is the Caloric Restriction Society, people who are losing weight in the hope of gaining years.  There is an on-line community of people experimenting with Buckyballs in olive oil (this may sound like a joke if you haven’t read about it before).

And then there is Jim Green of Wichita, KS.  Since 2007, Jim has been pursuing experimental strategies and claims to have set his body clock back by 15 to 20 years already.  The core of his program is telomerase activation herbs, particularly astragalus, taken in much larger quantities than the label recommends.  Jim has quite a story to tell, and this week I have interviewed him, an exclusive for ScienceBlog.

What gave you the idea that growing younger is possible

Jim Green 2007

Jim Green 2007

Jim Green 2013

Jim Green 2013

(You can read more about Jim’s career here and his anti-aging program here.)

According to the telomere position effect data I saw early on back in 2007, telomere length impacts youthful gene expression, and gene expression is more youthful the longer the telomeres are. Furthermore, since 1998 it has been realized thatsenescent cells can often be restored to the youthful phenotype by transfecting them with a virus that improves hTERT transcription and boosts levels oftelomerasee in the cell. In 1998,Michael Fossel published an article on this in the Journal of Anti-Aging Medicine (now Rejuvenation Research). [Another Fossel article -JJM] So there were definite grounds for optimism that lengthening telomeres with telomerase could result in rejuvenation transformations.

On the other hand, as telomeres got shorter, patterns of gene expression became more elderly and the likelihood of the onset of diseases of old ageincreased, according to many scientific studies. For instance, microglial cells in the brain that clean up amyloid betaplaque leading toAlzheimer’s disease fail when they become senescent. If senescence in the microglial cells (derived from hematopoietic stem cells) could be prevented, then Alzheimer’s disease due to the onset of senility might also be prevented. Similarly, when the lining of the vascular endothelium becomes senescent, it becomes more adhesive to monocytes and more likely to develop atherosclerotic plaque leading toattacks or strokes.  So taking small molecule telomerase activators effective at increasing the telomere length of components of the blood was a very good bet for effective life extension. Similarly, when dermal fibroblasts go senescent, they begin to attack theextracellular matrix, producing wrinkles. This does not happen at once to all of the fibroblasts, but gradually in a way that produces more and more defects in the extracellular matrix behind wrinkles. Thus a telomerase activator effective on dermal fibroblasts should prevent observable signs of old age such as wrinkles.

 

When did you start your program?  What was your program in the beginning?

I started taking telomerase activators on May 1, 2007, after reading material on TA-65 from TA Sciences.  I also had an exchange with Greta Blackburn of TA Sciences in which she emailed me promising results obtained by using TA-41, an astragalus extract which they believed would be similar in effect to TA-65.

At first I expected to be able to set back my telomere clock by up to 8 or 9 years per year, but subsequently revised this to about 5.1 years per year.

The astragalus extract actually finally turned out to work rather better, in fact, than TA-65.

I was also reading Life Extension Magazine since 2004, so I was familiar with supplements recommended by LEF to prevent diseases of old age, such as acetyl L-carnitine with alpha lipoic acid for mitochondria, L-arginine as a nitric oxide booster for rejuvenating the vascular endothelium, anticancer supplements such as garlic and gingerand turmeric, and so forth.

At first I took astragalus extracts such a Solaray Astragalus Extract, and tried GAIA Herbs astragalus extracts.  Later, I got the idea of using colostrum skin creams for telomerase activation. However I seem to have used astragalus extracts both orally and on my skin in the beginning.  This was done for two weeks before switching to atelomerase-inhibiting anticancer phase of treatment for the next two weeks, when I took medicine like curcumin, which is anticancer. If my telomerase activators tended at all to encourage cancer, I was going to squelch that every monthZin November 2009 I presented a short description of my program here For 2 1/2 years, I had relied primarily on astragalus extract for telomerase activation. However, I also got 5 grams of arginine per day to improve my nitric oxide levels and improve the length of endothelial progenitor cell telomeres.  By June of 2009 I concluded after studies of Vida Institute literature that 33 grams/day of astragalus root would serve as well or better than the 5 mg/day of astragalosides from astragalus extract that I computed I was taking. So I switched from pure astragalus extract like TA-41, which worked fine according to Greta Blackburn at TA Sciences, to astragalus root in capsules from NOW FOODS. However, I was still applying astragalus extract directly to my scalp.

[Editor’s note: Astragalus is a woody root which can be found in Chinese groceries for about $10/lb.  Traditional use would be to boil strips of astraglus to make a tea. -JJM]

What is your supplements regimen at present?  Is it still evolving?

I have posted a short summary of my present program and photo news here. It is still evolving, and by now I have 173 items at least on my list of telomerase activators that I am exploring. The numbers of the activators chronicle the order in which I found them in the literature, or were tipped off to them by other investigators, except for sub-items, which I have sometimes found more frequently.

I have continued a four-week cycle featuring telomerase activators for two weeks followed by anticancer telomerase inhibitors for two weeks.  I do things that permit cells to recover from the senescent state that are a little unusual now: I use folic acid in my colostrum solution with an amphipathic alcohol to improve absorption (rubbing alcohol = isopropyl alcohol). [Isopropyl alcohol is moderately toxic. – JJM]  I take carrots and exercise to inhibit P16INK4A, which can stop senescent cell recovery.

I have many ideas about medicine I would like to include, such as tocotrienol-rich fraction. [T
hese are chemical cousins of vitamin E derived from grains -JJM]  For bodybuilding, I take whey protein and creatine monohydrate, although I am not attempting a championship program. I can more easily resemble a gymnast.

Besides supplements, what are you doing to stay young?

Exercise improves circulation in the brain, elevates nitric oxide levels that dialate vessels, and provides numerous growth factor telomerase activators that can be separately enhanced by various nutraceuticals. So I work out with weights, about 6 sets per muscle, using a split routine that takes 3 or 4 days.  This might be dangerous to a person with too much atherosclerotic plaque, or someone with glycation stiffening in the veinous system from high levels of sugar from ice cream. However, it tends to lower triglycerides and improve the lipid profile, and also to improve confidence and mood.

I take a slice of Swiss cheese often to get a higher vitamin K2 level to avoid calcification of the arterial system and aortic stenosis.

In what ways do you feel younger than 7 years ago?

May 2007 was my starting date, and we are now approaching May 2014.  I would say that my confidence has improved that we can finally master aging, although there is still a fair amount of suspense involved.  My physical condition oscillates somewhat, and is subject to minor perturbations. I work to get leaner in the Spring, like most people, and my self-image improves then. I look better in photographs, although I invariably puff up a bit in the Winter. In the Summer I can do pull-ups on outside chinning bars, and I get more V-shaped.     In general, I seem to look somewhat better to myself in photographs an I did 7 years ago. Last Summer I did 130 pushups, which was    an all-time record for me. I am hoping that it will go back up to that this summer.

I notice you pay attention to appearance as well as health.  Do you think there’s a connection between anti-aging skin treatments and longevity?  Or a psychological effect whereby looking younger helps you to feel younger and programs your mind to live longer?

I could dress better to improve my appearance, but my funds vanish into supplements.  Wrinkles are definitely symptomatic of the formation of senescent cells which begin to excrete factors that attack the extracellular matrix and weaken it. A weaker extracellular matrix leads to more than cosmetic problems, eventually, and less resistance available to UV radiation from the sun.  So keeping the skin healthy and young is very important for survival as well as for image. Skin cancer kills. Thin skin and failing veil cells around veins can produce bleeding, finally, perhaps even dangerous internal bleeding.

Of course, looking younger creates a sense of optimism about what may be possible, and helps reinforce a positive attitude.

What evidence do you have that your body is really younger?

Unfortunately, I was unable to do measurements of my blood component telomere lengths because of funds could not be mobilized in time. Therefore, about all I have is my collection of photographs online. There are many measures of aging and senescence that may be applied to the problem of measuring the effect when funds are available.  Seehttp://www.greenray4ever.com/lifexmortality.html .

———-

* I wish I could say, “Testing experimental drugs on unsuspecting humans is off the table, out of the question, never done.”  The truth is that it is not as exceptional as we might wish.  And the institutions that resort to surreptitious experimentation are usually up to no good

 

Astragalus gegen Krebs

Über seinen Hinweis konnte ich Astragalus als interessantes Anti-Krebsmittel identifizieren, welches einen weiteren, nicht Telomer-Spezifischen Effekt im Tumrogeschehen zeigt:

Astragalus hemmt die s.g. regulatorischen T-Zellen (TREGS) welche im Tumor befindlich von diesem versklavt werden um das Immunsystem zu bremsen.

Dies ist der Gund, wieso die besten Immunstrategien in der Tumortherpie scheitern: wir können noch so viele Killerzellen mittels Mistel hochspritzen, noch so viele Dendritische Zellen primen und verabreichen, sobald diese in den Tumor wandern werden sie von TREG in den Winterschlaf geschickt.

Astragalus und einige andere Mittel sowie auch die „metronomische Chemotherapie“ wirken über Hemmung der TREG hilfreich in der Tumortherapie, ich habe hierzu eine eigene Seite (–> TREGs) verfasst.

Hier eine der Astragalus-TREG-Studien: aufregende Studie aus 2012 

Astragalus hab ich nun dank Dr. Zöch auf meine Watchlist gesetzt, wir werden versuchen ein gutes Präparat zu finden!

 

Weitere Links

Bei Phytodoc hab ich schöne Zusammenfassungen gefunden

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HeliR
HeliR
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2 Kommentare

  1. Dennis sagt:

    ASTRAGALUS membranaceus ist dieses homöopatische mittel dazu gegeignet die telomere zu verlängern wenn ja in welcher Potzenz

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